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Class: allosteric regulation (AllostericRegulation)

Allosteric activation or inhibition of an enzyme by an effector that binds at a site distinct from the catalytic (active) site.

URI: chemrof:AllostericRegulation

 classDiagram
    class AllostericRegulation
    click AllostericRegulation href "../AllostericRegulation/"
      EnzymeRegulation <|-- AllostericRegulation
        click EnzymeRegulation href "../EnzymeRegulation/"

      AllostericRegulation : effector





        AllostericRegulation --> "1" ChemicalEntity : effector
        click ChemicalEntity href "../ChemicalEntity/"



      AllostericRegulation : modification_type





        AllostericRegulation --> "1" EnzymeModificationTypeEnum : modification_type
        click EnzymeModificationTypeEnum href "../EnzymeModificationTypeEnum/"



      AllostericRegulation : owl_subclass_of





        AllostericRegulation --> "0..1" OwlClass : owl_subclass_of
        click OwlClass href "../OwlClass/"



      AllostericRegulation : regulated_enzyme

Inheritance

Slots

Name Cardinality and Range Description Inheritance
modification_type 1
EnzymeModificationTypeEnum		 Whether the allosteric effector activates or inhibits the enzyme direct
effector 1
ChemicalEntity		 The chemical entity (typically a metabolite) that exerts the regulatory effec... EnzymeRegulation
regulated_enzyme 0..1
String		 Optional identifier or label of the specific enzyme (isoform) that is regulat... EnzymeRegulation
owl_subclass_of 0..1
OwlClass		 Holds between C and P if C owl:subClassOf P OwlClass

Usages

used by used in type used
Reaction has_allosteric_regulation range AllostericRegulation
IsomeraseReaction has_allosteric_regulation range AllostericRegulation

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/chemrof

Mappings

Mapping Type Mapped Value
self chemrof:AllostericRegulation
native chemrof:AllostericRegulation

LinkML Source

Direct

name: AllostericRegulation
description: Allosteric activation or inhibition of an enzyme by an effector that
  binds at a site distinct from the catalytic (active) site.
title: allosteric regulation
from_schema: https://w3id.org/chemrof
is_a: EnzymeRegulation
attributes:
  modification_type:
    name: modification_type
    description: Whether the allosteric effector activates or inhibits the enzyme.
    from_schema: https://w3id.org/chemrof
    rank: 1000
    domain_of:
    - AllostericRegulation
    range: EnzymeModificationTypeEnum
    required: true

Induced

name: AllostericRegulation
description: Allosteric activation or inhibition of an enzyme by an effector that
  binds at a site distinct from the catalytic (active) site.
title: allosteric regulation
from_schema: https://w3id.org/chemrof
is_a: EnzymeRegulation
attributes:
  modification_type:
    name: modification_type
    description: Whether the allosteric effector activates or inhibits the enzyme.
    from_schema: https://w3id.org/chemrof
    rank: 1000
    alias: modification_type
    owner: AllostericRegulation
    domain_of:
    - AllostericRegulation
    range: EnzymeModificationTypeEnum
    required: true
  effector:
    name: effector
    description: The chemical entity (typically a metabolite) that exerts the regulatory
      effect.
    from_schema: https://w3id.org/chemrof
    rank: 1000
    alias: effector
    owner: AllostericRegulation
    domain_of:
    - EnzymeRegulation
    range: ChemicalEntity
    required: true
  regulated_enzyme:
    name: regulated_enzyme
    description: Optional identifier or label of the specific enzyme (isoform) that
      is regulated. A reaction may be catalyzed by more than one enzyme, and a regulatory
      effect may apply to only some of them.
    from_schema: https://w3id.org/chemrof
    rank: 1000
    alias: regulated_enzyme
    owner: AllostericRegulation
    domain_of:
    - EnzymeRegulation
    range: string
  owl_subclass_of:
    name: owl_subclass_of
    annotations:
      owl:
        tag: owl
        value: SubClassOf
    description: 'Holds between C and P if C owl:subClassOf P. Note that in this model,
      most classes are metaclasses (see ''owl class''), where these metaclasses may
      represent *groupings* or specific countable elements or species. We provide
      two different sub-properties of subclass of for two cases: (1) subtype_of, which
      connects grouping classes (e.g. alkane is_a hydrocarbon; alpha-amino-acid is_a
      amino-acid), (2) classified_by, which connects a specific element to a grouping
      class (e.g. methane is_a hydrocarbon; iron is_a metal; serine is_a amino-acid)'
    title: owl subclass of
    from_schema: https://w3id.org/chemrof
    aliases:
    - is a
    exact_mappings:
    - rdfs:subClassOf
    narrow_mappings:
    - bo:family
    rank: 1000
    is_a: classification_relationship
    mixin: true
    domain: OwlClass
    alias: owl_subclass_of
    owner: AllostericRegulation
    domain_of:
    - OwlClass
    range: OwlClass